The Last Man on Earth is a 1964 post-apocalyptic science fiction horror film based on the 1954 novel I Am Legend by Richard Matheson. The film was produced by Robert L. Lippert and directed by Ubaldo Ragona and Sidney Salkow, and stars Vincent Price and Franca Bettoia. The screenplay was written in part by Matheson, but he was dissatisfied with the result and chose to be credited as "Logan Swanson". William Leicester, Furio M. Monetti, and Ubaldo Ragona finished the script.

The Last Man on Earth was filmed in Rome, with scenes being completed at Esposizione Universale Roma. It was released in the United States by American International Pictures. In the 1980s, the film entered the public domain. MGM Home Video, the current owners of the AIP film catalog, released a digitally remastered widescreen version of the film on DVD in September 2005. In 2014, Scream Factory released Blu-ray version in the Vince Price Collection II, which included six other Vincent Price films.