Of Mice and Men is a 1992 American period drama film directed by Gary Sinise from a screenplay by Horton Foote. Based on John Steinbeck's 1937 novella of the same name, it stars John Malkovich as the intellectually disabled Lennie and Sinise as George, two farm workers who travel together and dream of one day owning their own land. Like the novella, it explores themes of discrimination, loneliness, and the American Dream, as well as the desire for a place to call home.

Of Mice and Men took part in the 1992 Cannes Film Festival, where Sinise was nominated for the Palme d'Or award, given to the director of the best-featured film. After the film debuted in the United States on October 2, 1992, it received acclaim from critics.